Copy of Platelet-base control of the coagulation process – essential in thrombosis and haemostasis
As part of the GIGA Conferences cycle, the GIGA-Cardiovascular Sciences Thematic Unit has invited Professor Johan (J.W.M.) Heemskerk from the CARIM School for Cardiovascular Diseases who will hold a conference about thrombosis and hemostasis.
The program focuses on blood platelets and their role in the stimulation of coagulation and more specifically on: (i) new intracellular signalling peptides that are identified (phospho) proteomics analyses and (ii) new mutations of known signalling peptides.
A key technology used is real-time microscopic imaging, which is adapted to study thrombus formation ex vivo with flow-chamber technology as well as thrombus formation in vivo in the living animal and enables multi-probe real-time imaging of thrombus formation. Effects of thrombus formation are also studied in the development of an atherosclerotic plaque, inflammation, angiogenesis and vascular repair.