GIGA-Systems Biology & Chemical Biology

The TRU in "Systems Biology and Chemical Biology" of GIGA-R has the mission to develop the research at GIGA-R in bioinformatics, systems biology, and chemical biology.

This thematic research unit has a highly interdisciplinary team of about fifty researchers (engineers, computer scientists, statisticians, biologists, chemists, physicists). They develop instrumentation techniques for high throughput biological data and image acquisition, as well as methods, algorithms and software packages for the exploitation of proteomics, genomics, metabolomics, cellulomics and physiomics data and images. Their research also aims at developing static and dynamic modeling approaches for gene expression regulation, signalling and metabolomic networks, and to apply these methods in the context of research projects in collaboration with other thematic research units of GIGA-R and outside of the University of Liège.

Head of the thematic research unit
Kristel Van Steen



Research project


Research units

Molecular biology & genetic engineering See more
    Cécile Van De Weerdt

Bioinformatics & modelisation See more
    Louis Wehenkel

Mass spectrometry See more
    Edwin De Pauw

    Marie-Claire De Pauw-Gillet   




Significant publications

Collie GW, Parkinson GN, Neidle S, Rosu F, De Pauw E, Gabelica V.
Electrospray mass spectrometry of telomeric rna (terra) reveals the formation of stable multimeric g-quadruplex structures.
J Am Chem Soc. 2010;132:9328-9334 See more
Meuwis MA, Fillet M, Lutteri L, Marée R, Geurts P, deSeny D, Malaise M, Chapelle JP, Wehenkel L, Belaiche J, Merville MP, Louis E.
Proteomics for prediction and characterization of response to infliximab in Crohn Disease: a pilot study.
Clinical Biochemistry 2008 Aug; 41(12):960-967

Bogaert V, Taes Y, Konings P, Van Steen K, De Bacquer D, Goemaere S, Zmierczak H, Crabbe P, Kaufman JM.
Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings.
Clinical Endocrinology 2008 Jun;69(1):129-135.

Mazzucchelli GD, Gabelica V, Smargiasso N, Fléron M, Ashimwe W, Rosu F, De Pauw-Gillet MC, Riou JF, De Pauw E. 
Proteome alteration induced by hTERT transfection of human fibroblast cells.
Proteome Sci, 2008 Apr; 6:12.

Stan G-B, Belmudes F, Fonteneau R, Zeggwagh F, Lefebvre M-A, Michelet C, Ernst D.
Modelling the influence of activation-induced apoptosis of CD4+ and CD8+ T-cells on the immune system response of a HIV infected patient.
IET Systems Biology 2008 Mar;2(2):94-102.

Maes D, Evrard C, Gavira J, Sleutel M, Van De Weerdt C, Otalora F, Garcia-Ruiz JM, Nicolis G, MartialJ, Decanniere K.
Towards a definition of X-ray crystal quality
Crystal Growth and Design 2008, to appear.

Evrard C, Maes D, Zegers I, Declercq JP, Vanhee C, Martial J, Wyns L, Van de Weerdt C.
TIM crystal grown by capillary counter-diffusion: Statistical evidence of quality improvement in microgravity.
Crystal Growth and Design 2007; 7: 2161-2166.

Bozukova D, Pagnoulle C, De Pauw-Gillet MC, Ruth N, Jérôme R, Jérôme C.
Imparting antifouling properties of poly(2-hydroxyethyl methacrylate) hydrogels by grafting poly(oligoethylene glycol methyl ether acrylate).
Langmuir, 2008 May; 1;24(13).

Mazzucchelli GD, Cellier NA, Mshviladzade V, Elias R, Shim YH, Touboul D, Quinton L, Brunelle A, Laprévote O, De Pauw EA, De Pauw-Gillet MC. 
Pores formation on cell membranes by hederacolchiside A1 leads to a rapid release of proteins for cytosolic subproteome analysis.  
J Proteome Res. 2008 Mar; 7(4):1683-92.

Teschendorff AE, Journée M, Absil PA, Sepulchre R, Caldas C.
Elucidating the Altered Transcriptional Programs in Breast Cancer using Independent Component Analysis.
PLoS Computational Biology 2007 Aug;3(8):1539-1554.

Bozukova D, Pagnoulle C, De Pauw-Gillet MC, Desbief S, Lazzaroni R, Ruth N,Jérôme R, Jérôme C. 
Improved performances of intraocular lenses by poly(ethylene glycol) chemical coatings.
Biomacromolecules. 2007 Aug; 8(8):2379-87

Gerkens PC, Dobson R, Tabatadze N, Mshviladzade V, Elias R, Peulen OJ, Jolois OM, De Pauw-Gillet MC.
Apoptosis and cytolysis induced by giganteosides and hederacolchisides inHL-60 cells.
Anticancer Res, 2007 Jul-Aug ; 27(4B):2529-34.

Marée R, Geurts P, Wehenkel L.
Random Subwindows and Extremely Randomized Trees for Image Classification in Cell Biology.
BMC Cell Biology 2007 Jul;8(Suppl 1):S2.

Meuwis MA, Fillet M, Geurts P, deSeny D, Lutteri L, Chapelle JP, Bours V, Wehenkel L, Belaiche J, Malaise M, Louis E, Merville MP.
Biomarker discovery for Inflammatory Bowel Disease, using proteomic serum profiling.
Biochemical Pharmacology 2007 May;73(9):1422-1433.

Geurts P, Touleimat N, Dutreix M, d’Alché-Buc F.
Inferring biological networks with output kernel trees.
BMC Bioinformatics 2007 May;8(Suppl 2):S4.

See all the GIGA publications