GIGA-Neurosciences

The GIGA-neurosciences unit was established at the University of Liege in 1999 as the Center for Cellular and Molecular Neurobiology (CNCM). The center at that time consisted of various laboratories which shared a common interest : the nervous system. Scattered geographically in 1999, these laboratories were combined into a single site in June 2005. During the move, a real pooling of technical resources of each laboratory was done, and led to the establishment of five technical platforms: cell culture, histology, molecular biology, electrophysiology and confocal imaging. Much more than just a pooling of technical resources, this consolidation has allowed scientific interactions among groups and researchers, resulting in an increase in the quality of work and the results reflected currently in terms of publications. In 2009, the CNCM integrated GIGA-Research as  "Neurosciences" thematic unit. This unit has established strong links with the clinical departments of Neurology, Neurosurgery and Neuropsychology the University Hospital, and with the Cyclotron Research Center focussed on functional neuroimaging technologies. The GIGA-neurosciences unit promotes the exchange of research findings, especially the knowledge of new techniques, and provides the necessary facilitis for students to become Neuroscientists.
 
malgrange 

Head of the thematic research unit
Brigitte Malgrange

 


Research projects

 

Research units

Behavioral Neuroendocrinology See more
    Jacques Balthazart, Julie Bakker

Bioénergétique, excitabilité et plasticité cérébrale See more
   Lucien Bettendorff, Thierry Grisar, Bernard Lakaye

Developmental Neuroendocrinology
   Jean-Pierre Bourguignon

Developmental Neurobiology See more
   Brigitte Malgrange, Bernard Rogister, Laurent Nguyen, Pierre Leprince

Electrophysiology See more
   Vincent Seutin

Axonal regeneration and cephalic pain
   Jean Schoenen, Rachelle Franzen

Cellular and tissular biology
   Marc Thiry
 

Advisory Board

  • Luis Miguel Garcia-Segura (Instituto Cajal, Madrid, Spain)
  • Elbert Joosten (Academic Hospital, Utrecht, The Netherlands)
  • John Parnavelas (University College London, UK)
  • Fritz Rathjen (MDC for molecular medicine, Berlin, Deutschland)

Significant publications

Schoenen J, Coppola G.
Headache: spreading from molecules to patients.
Lancet Neurol 2010;9(1):11-12. See more

Heng JI, Chariot A, Nguyen L.
Molecular layers underlying cytoskeletal remodelling during cortical development.
Trends Neurosci 2010;33(1):38-47. See more

Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O,Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, MalgrangeB,Chapelle JP, Siebenlist U, Moonen G, Chariot A* and  Nguyen L*(*Equal contributions)
Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin
Cell (2009), 136, 551-564

de Nijs L, Leon C, Nguyen L, LoTurco JJ, Delgado-Escueta AV, Grisar T, Lakaye B.
EFHC1 interacts with microtubules to regulate cell division and cortical development.
Nature Neuroscience 2009;12(10):1266-U1284.

Heng JI, Chariot A, Nguyen L.
Molecular layers underlying cytoskeletal remodelling during cortical development.
Trends Neurosci 2009.

Rouchet N, Waroux O, Lamy C, Massotte L, Scuvee-Moreau J, Liegeois JF, Seutin V.
SK channel blockade promotes burst firing in dorsal raphe serotonergic neurons.
Eur J Neurosci 2008;28(6):1108-1115.

Thiry M, Lamaye F, Thelen N, Chatron-Colliet A, Lalun N, Bobichon H, Ploton D.
A protocol for studying the kinetics of RNA within cultured cells: application to ribosomal RNA.
Nat Protoc 2008;3(12):1997-2004.

Bakker J, De Mees C, Douhard Q, Balthazart J, Gabant P, Szpirer J, Szpirer C.
Alpha-fetoprotein protects the developing female mouse brain from masculinization and defeminization by estrogens.
Nat Neurosci 2006;9(2):220-226.

Balthazart J, Ball GF.
Is brain estradiol a hormone or a neurotransmitter?
Trends Neurosci 2006;29(5):241-249.

BettendorffL, Wirtzfeld B, Makarchikov AF, Mazzucchelli G, Frederich M,Gigliobianco T, Gangolf M, De Pauw E, Angenot L, Wins P.
Discovery of a natural thiamine adenine nucleotide.
Nat Chem Biol 2007;3(4):211-212.

Bouhy D, Malgrange B, Multon S, Poirrier AL, Scholtes F, Schoenen J, Franzen R.
DelayedGM-CSF treatment stimulates axonal regeneration and functional recoveryin paraplegic rats via an increased BDNF expression by endogenousmacrophages.
FASEB J 2006;20(8):1239-1241.

 


See all the GIGA publications